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Webinar: Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
Tuesday 21 July 2020 - 01:00pm - Tuesday 21 July 2020 
Clarity-BPA studies

Jerry Heindel, will present an overview of the CLARITY-BPA program and an introduction to the current publication, “Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies,” to set the stage for the other speakers.

The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) is a comprehensive “industry-standard” Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. This study was funded and coordinated by the US FDA, the National Toxicology Program, and the National Institute of Environmental Health Sciences, Division of Extramural Research and Training. The fourteen funded investigator-initiated studies were focused on integrating disease-associated, molecular, morphological and physiological endpoints previously found by academic scientists into a guideline-compliant toxicity study. Thus, the goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints. The goal of this current publication is to integrate the findings from eight of the investigator-initiated studies into a comprehensive overview of the observed impacts of BPA across the multiple organs and systems analyzed. For each organ system, authors provide the rationale for the study, an overview of methodology, and summarize major findings. They then compare the results of the CLARITY-BPA studies across organ systems with the results of previous peer-reviewed studies from independent labs. They also discuss potential influences that contributed to differences between studies. Finally, they interpret the findings in light of the current regulatory guidelines for BPA.

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