Events Calendar

Webinar: Chemical Mixtures and Cancer
Wednesday 20 May 2020 - 02:00pm - Wednesday 20 May 2020 03:10pm
Collaborative on Health and the Environment

In real world settings, exposure to individual environmental contaminants does not happen in isolation. Humans are exposed to many different chemical mixtures throughout their life. However, suspected environmental risk factors for cancer are most often evaluated one at a time. In response to this, scientists are developing new strategies to better understand cumulative exposures and chemical mixtures in relationship to cancer-related outcomes. Weighted quantile sum (WQS) regression is a biostatistical modeling strategy that determines an empirically-estimated weighted index of correlated components (e.g., environmental chemicals) associated with an outcome variable (e.g., risk of cancer), adjusted for covariates. Using a case study, Dr. Chris Gennings will present WQS regression in an analysis of a mixture of 27 correlated chemicals measured in house dust and risk of non-Hodgkin lymphoma.

Following this presentation, Dr. Shanaz Dairkee will describe the effects of environmentally relevant concentrations of single versus mixed xenoestrogens upon known cancer promoting cellular pathways within estrogen-responsive healthy human breast cells. Using this experimental model system, she will present data on the comparative response of non-malignant breast epithelium and breast cancer cell lines to illustrate the significance of incorporating appropriate target cells and endpoints in assays for chemical safety assessment.

To conclude, Dr. Nicole Niehoff will present results from her study on airborne mammary carcinogens and breast cancer risk. In this research, Dr. Niehoff examined 29 air toxics, with concentrations estimated from the 2005 National Air Toxics Assessment, in relation to breast cancer risk among 49,718 women in the prospective and nationwide Sister Study cohort. Classification trees were used to determine patterns and combinations of multiple pollutants that were more or less harmful for breast cancer compared to single pollutants.

Learn more about the speakers and register here.

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