Events Calendar

Webinar: Glyphosate: Review of Animal Carcinogenicity Data and Epigenetic Impacts
Wednesday 13 May 2020 - 02:00pm - Wednesday 13 May 2020 02:45pm
Collaborative on Health and the Environment

Register for the webinar here.

There is considerable controversy concerning the carcinogenicity of glyphosate, with scientists and regulatory authorities involved in the review of glyphosate having markedly different opinions. One key aspect of these opinions is the degree to which glyphosate causes cancer in laboratory animals after lifetime exposure. In addition, the acknowledgment that pollutants such as glyphosate might influence the epigenome raises serious concerns regarding its long-term impact on the development of cancer. However, reports on glyphosate demonstrate the difficulty of linking estimates of exposure and response analysis.

During the webinar, Dr. Christopher Portier will present of a review of animal carcinogenicity data after exposure to glyphosate. Dr. Portier and colleagues identified twenty-one chronic exposure animal carcinoenicity studies of glyphosate from regulatory documents and reviews. Thirteen studies that were of sufficient quality and detail were reanalyzed and presented in this review using trend tests, historical control tests, and pooled analyses.

Following this presentation, Manon Duforestel will discuss a synergistic approach she and colleagues used to assess the potential risk impact for cancer, as cancer rarely occurs in response to just one risk factor. The known influence of glyphosate on estrogen-regulated pathway makes it a logical target of investigation in breast cancer research. For this purpose, she and colleagues postulated that glyphosate could induce breast cancer by itself or in combination with other oncogenic hits, in line with the multiple-hit theory of carcinogenesis. They chose to analyze the carcinogenicity of glyphosate combined with a second oncogenic hit: the overexpression of miRNAs known to be involved in tumor progression and aggressiveness. In this context, their findings revealed that glyphosate induces global DNA hypomethylation in non-neoplastic mammary epithelial MCF10A cells and contributes to tumorigenesis in a “two-hit oncogenic model.” Their data also uncovered a specific DNA hypomethylation signature of genes related to the TET3 pathway that might be used as epimark of glyphosate exposure.

Read more about the speakers and register here.

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